Thanks for suggestions!
We tried using a very tiny bit of color, which was pretty neat - I might put an option back in for it. You have to go pretty far, or it basically looks the same.
What I think is happening is that a "natural" palette like you'd see outdoors just doesn't have a lot of super-saturated colors, and these colors we're seeing on computer screens are so saturated that we have to dial them back a ton before they aren't really noticeable. I wish we could target just the unnatural ones and leave most of the rest.
Regarding regions: it is a good idea / may be possible in the future, but full-screen is the most reliable thing we can do for now.