I've been having this for quite some time, it's really annoying. Every time after the PC has been in sleep and I wake it, F.lux has shut down, and not every time is it working to start it up again.
Driver info
NVIDIA 27.21.14.6109: NVIDIA GeForce RTX 3070 (20201231)
Generic PnP Monitor, 597 x 336mm, built 2020
Chromaticities:
R=0.651367 0.327148
G=0.291992 0.596680
B=0.148438 0.059570
W=0.313477 0.329102
sRGB gamut: 98%, AdobeRGB gamut: 65%
ASUS VG27A(DisplayPort), 597 x 336mm, built 2019
Chromaticities:
R=0.658203 0.333008
G=0.299805 0.626953
B=0.148438 0.056641
W=0.312500 0.328125
sRGB gamut: 100%, AdobeRGB gamut: 72%
Winlimit=0, 0
Monitor 1 on NVIDIA GeForce RTX 3070: VCGT=0 gamma=1
Monitor 2 on NVIDIA GeForce RTX 3070: VCGT=0 gamma=1
Windows Build: 19042.685