Same thing on a Lenovo Thinkbook laptop, with the latest Intel Graphics drivers. The pixels don't appear on a screenshot of a problematic image.

Windows: 18363.1256 (Windows 10 1909)
Provider: Intel Corporation
Version: 27.20.100.9030
Date: 27/11/2020
Video Processor: Intel® Iris® Graphics Family
Device Id: PCI\VEN_8086&DEV_8A52&SUBSYS_385217AA&REV_07\3&11583659&1&10

EDIT : there's a larger topic about the issue https://forum.justgetflux.com/topic/7279/red-screen-artifacts-when-flux-is-on/

Just set the colors all the same. Go to the f.lux menu on the main interface, and choose "Adjust day and night colors together..."

Just made an account here to report the same issue. Yesterday I updated both windows update and Nvidia drivers to the newest versions and after that f.lux doesn't disable when I play games in fullscreen anymore. So now the only way not having to play games that look all orange is to exit/disable f.lux altogether. Please fix (:

Try this article:
https://support.displaylink.com/knowledgebase/articles/1886413-how-to-enable-night-light-or-f-lux-on-displaylink

This isn't caused by f.lux. You need to do some digging to see what was installed and get rid of it.

Can you post f.lux options > driver info?

@herf That's the solution! Thanks!

Ok, I updated and restarted my comp and it's back! woo.

NVIDIA 27.21.14.5206: NVIDIA GeForce GTX 1070 (20200812)

Generic PnP Monitor, 575 x 323mm, built 2018
Chromaticities:
R=0.655273 0.325195
G=0.264648 0.583984
B=0.140625 0.131836
W=0.290039 0.328125
sRGB gamut: 90%, AdobeRGB gamut: 66%

Generic PnP Monitor, 531 x 299mm, built 2016
Chromaticities:
R=0.645508 0.330078
G=0.309570 0.617188
B=0.152344 0.073242
W=0.313477 0.329102
sRGB gamut: 99%, AdobeRGB gamut: 68%

Winlimit=0, 0
Monitor 1 on NVIDIA GeForce GTX 1070: VCGT=0 gamma=1
Monitor 2 on NVIDIA GeForce GTX 1070: VCGT=0 gamma=1

Windows Build: 19041.630

Turn off "Night light" in Windows. It's in Settings > System > Display. You'll find it at the very top.

Interesting stuff, I didn't know that. I can't find my laptop's lcd profile on the database, I will check QuickGamma for sure.
Thank you.

Sorry herf, I though that i'llreceive an email for answers...
So i look at driver info on tuesday because I'm not near the concern computer.
thank'you very much !

There is a detail view with three sliders, so you can adjust all the parts of the schedule at once.

But my recommendation is that you should reinstall just in case the resource files became corrupted.