OK, I spoke too soon. It stopped working again tonight. Not sure why. The only relevant piece of information is that I restarted my computer earlier, but why would that make f.lux not work? The settings say it's working, but the color hasn't actually changed on my screen.
I quit the app and restarted, and no difference.
Anyway, here's the driver info:
Intel Corporation 27.20.100.8935: Intel(R) UHD Graphics (20201028)
NVIDIA 27.21.14.6280: NVIDIA GeForce GTX 1650 Ti (20210609)
Fresco Logic 2.1.34054.0: Fresco Logic IDDCX Adapter (20171113)
AOC 2343, 509 x 286mm, built 2012
Chromaticities:
R=0.648438 0.338867
G=0.282227 0.602539
B=0.142578 0.070313
W=0.313477 0.329102
sRGB gamut: 92%, AdobeRGB gamut: 64%
Generic PnP Monitor, 344 x 194mm, built 2018
Chromaticities:
R=0.648438 0.344727
G=0.333984 0.616211
B=0.150391 0.057617
W=0.312500 0.328125
sRGB gamut: 83%, AdobeRGB gamut: 58%
Unlimited gamma ramp=1, Internal ramp=0
Monitor 1 on Fresco Logic IDDCX Adapter
Has VCGT profile=0, Gamma Ramp works=1
Windows Build: 19042.1237