@DCRnash We did this on old dual-GPU macs from the 2012-2015 era. We found they would switch from discrete to integrated GPU and load the system colors, but not the f.lux ones.
On newer Apple Silicon macs, there is no switch (since there is just one GPU) and so we don't have to build a profile to keep things working. It's better in most cases for f.lux to be a "temporary" effect. But in case you somehow wanted the old behavior, it might still work with a pref - check out: https://justgetflux.com/news/2014/10/28/profile.html